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KMID : 0043320100330070999
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Archives of Pharmacal Research
2010 Volume.33 No. 7 p.999 ~ p.1003
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Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells
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Na Chae-Sun
Hong Seong-Su
Choi Yun-Hyeok
Lee Yong-Ho
Hong Sun-Hee
Lim Ji-Youn
Kang Byeong-Hoa
Park So-Young
Lee Dong-Ho
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Abstract
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A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (Aβ) using PC12 cells, a major cause of the pathology of Alzheimer’s disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 μM against Aβ-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 μM, respectively.
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KEYWORD
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Eragrostis ferruginea, Poaceae, 7-Demethylageconyflavone A, Beta-amyloid, Neuroprotection
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